| 2-氟-5-溴硝基苯的合成 |
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| 引用本文： | 陈兴权. 2-氟-5-溴硝基苯的合成[J]. 精细化工, 2012, 29(1): 73-76 |
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| 作者姓名： | 陈兴权 |
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| 作者单位： | 常州大学石油化工学院 |
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| 基金项目： | 江苏省教育厅高校自然科学基础研究项目 |
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| 摘 要： | 采用冰醋酸作为溶剂,以邻氟硝基苯为原料,N-溴代丁二酰亚胺(NBS)为溴代试剂,合成了2-氟-5-溴硝基苯。所得目标产物通过GC-MS定性、GC定量检测。结果表明,最佳反应条件为:n(邻氟硝基苯)∶n(NBS)=1∶1.05,以冰醋酸作溶剂,反应温度10℃,反应时间2 h,在该条件下2-氟-5-溴硝基苯的收率为98.6%,原料转化率100%。该反应条件温和,易于控制,重复性好。
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| 关 键 词： | 邻氟硝基苯 冰醋酸 溴代 2-氟-5-溴硝基苯 精细化工中间体 |
| 收稿时间： | 2011-09-20 |
| 修稿时间： | 2011-11-08 |
Synthesis of 2-fluoro-5-bromonitrobenzene |
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| CHEN Xing-quan. Synthesis of 2-fluoro-5-bromonitrobenzene[J]. Fine Chemicals, 2012, 29(1): 73-76 |
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| Authors: | CHEN Xing-quan |
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| Affiliation: | (Institute of Petrochemical Technology,Changzhou University,Changzhou 213164,Jiangsu,China) |
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| Abstract: | 2-Fluoro-5-bromonitrobenzene was prepared from 2-fluoronitrobenzene,using acetic acid(CH3COOH),instead of sulfuric acid or boron trifluoride,as solvent,and N-bromosuccinimide(NBS) as bromide reagent.The reaction conditions were mild and easy to control.The qualitative analysis of the target product was carried out by means of GC-MS and the quantification was carried out by means of GC.The best yield(98.6%) of 2-fluoro-5-bromonitrobenzene and conversion(100%) of 2-fluoronitrobenzene were obtained under optimized conditions that n(2-fluoronitrobenzene)∶ n(NBS)=1∶ 1.05,the reaction temperature was 10 ℃ and the reaction time was 2 h.The repeat experiments show that the technology had a good repeatability under the above optimum conditions. |
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| Keywords: | 2-fluoronitrobenzene acetic acid bromide 2-fluoro-5-bromonitrobenzene |
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