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| 丙烯醛温和液相反应制备3-甲基吡啶工艺 | |
| 引用本文： | 王开明,潘金钢,王展旭,李国强.丙烯醛温和液相反应制备3-甲基吡啶工艺[J].精细化工,2012,29(1):82-85. |
| 作者姓名： | 王开明 潘金钢 王展旭 李国强 |
| 作者单位： | 1. 青岛科技大学化学与分子工程学院,山东青岛 266042;北京华地博源生化科技有限公司,北京 100120;中国海洋大学医药学院,山东青岛 266003 2. 北京华地博源生化科技有限公司,北京,100120 3. 青岛科技大学化学与分子工程学院,山东青岛,266042 4. 中国海洋大学医药学院,山东青岛,266003 |
| 基金项目： | 国家自然科学基金项目（面上项目，重点项目，重大项目） |
| 摘 要： | 以丙烯醛为原料，通过单因素实验，建立了优化的温和液相反应合成3-甲基吡啶的优化工艺条件：以乙二醇单丁醚为溶剂，反应温度140℃，料液比n(丙烯醛):n(乙二醇单丁醚)=1:33，n(丙烯醛):n(乙酸铵)=1:8，w(丙烯醛正丁酸溶液)=8%，m(丙烯醛):m(SO24-/TiO2-HZSM-5催化剂)=1:1.4。在优化条件下，实现了丙烯醛转化率100%，3-甲基吡啶选择性49.92%。 |
| 关 键 词： | 3-甲基吡啶 丙烯醛 液相反应 工艺优化 |
| 收稿时间： | 2011/8/25 0:00:00 |
| 修稿时间： | 2011/11/4 0:00:00 |
Study on Preparation Process of 3-Picoline by Mild Liquid Phase Reaction of Acrolein |
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| WANG Kai-ming,PAN Jin-gang,WANG Zhan-xu and LI Guo-qiang.Study on Preparation Process of 3-Picoline by Mild Liquid Phase Reaction of Acrolein[J].Fine Chemicals,2012,29(1):82-85. | |
| Authors: | WANG Kai-ming PAN Jin-gang WANG Zhan-xu and LI Guo-qiang |
| Affiliation: | College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology,Beijing Huadi Boyuan Bio-Chemical Techmology Co Ltd,Qingdao University of Science and Technology,School of Medicine and Pharmacy, Ocean University of China |
| Abstract: | This paper is to report an optimum preparation process of 3-picoline by mild liquid phase reaction of acrolein based on single factor design method.The reaction was carried out in the solvent of ethylene glycol monobutyl ether at 140 ℃ of temperature for 1 h,the mole ratio of acrolein and acetic ammonium and ethylene glycol monobutyl ether being 1∶ 8∶ 33,the mass ratio of acrolein and catalyst SO42-/TiO2-HZSM-5 being 1∶ 1.4,and the mass percent of acrolein in n-butyric acid being 15%.Under the optimized conditions,the conversion rate of acrolein reached 100% and the yield of the selectivity of 3-picoline reached 49.92%. |
| Keywords: | 3-picoline acrolein liquid phase reaction synthetic process |
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