| IL-8动员造血细胞救治致死性照射小鼠的初步研究 |
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| 引用本文： | 刘玉龙,周剑影,王国权,戴宏,段莹莹,郭晓葵,李元. IL-8动员造血细胞救治致死性照射小鼠的初步研究[J]. 辐射防护通讯, 2001, 21(3): 19-21,30 |
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| 作者姓名： | 刘玉龙 周剑影 王国权 戴宏 段莹莹 郭晓葵 李元 |
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| 作者单位： | 苏州大学附属第二医院,苏州,215004 |
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| 基金项目： | 国防科工委“九五”国防预研资助项目 (57.3 .1 ) |
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| 摘 要： | 将人重组白细胞介素－8(rhIL-8）动员的雄性小鼠外周血单个核细胞（MNCs）静脉输注给受到8．5Gy照射的同种雌性小鼠，并对存活的受体小鼠进行Y染色体PCR检测。结果表明，经rhIL－8动员的造血干／祖细胞可使受照射小鼠长期重建造血。提示rhIL－8具有快速有效的动员造血细胞的作用。
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| 关 键 词： | 白细胞介素－8 放射损伤 动员剂 造血干细胞 治疗 造血细胞 |
| 文章编号： | 1004-6356(2001)03-0019-04 |
Preliminary Study on IL-8 Inducing Mobilization of Hematopoietic Cells to Rescue Lethally Irradiated Mice |
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| Liu Yulong Zhou Jianying Wang Guoquan Dai Hong Duan Yingying Guo Xiaokui Li Yuan. Preliminary Study on IL-8 Inducing Mobilization of Hematopoietic Cells to Rescue Lethally Irradiated Mice[J]. Radiation Protection Bulletin, 2001, 21(3): 19-21,30 |
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| Authors: | Liu Yulong Zhou Jianying Wang Guoquan Dai Hong Duan Yingying Guo Xiaokui Li Yuan |
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| Abstract: | The peripheral blood mononucleus cells(MNCs) mobilized by recombinant human interleukin 8 (rhIL 8) were transplanted from male mice to lethally irradiated(8.5 Gy) recipient female mice.The peripheral blood cells of the recipient female mice which were transplanted with MNCs obtained from rhIL 8 treated male donors were determined in using a Y chromosome specific probe(PCR analysis).In addition to their radioprotective capacity,the MNCs mobilized by rhIL 8 showed also long term repopulating ability to the lethally irradiated mice.It was proved that rhIL 8 had rapid and potent effect of mobilizing hematopoietic cells. |
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| Keywords: | Interleukin 8 BALB/c mouse Radiation injury Mobilization agent Hematopoietic stem/progenitor cells |
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