| 磁性壳聚糖复合微球的制备和性能研究 |
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| 引用本文： | 姜炜,李凤生,杨毅,刘宏英,楚建军.磁性壳聚糖复合微球的制备和性能研究[J].材料科学与工程学报,2004,22(5):660-662. |
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| 作者姓名： | 姜炜 李凤生 杨毅 刘宏英 楚建军 |
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| 作者单位： | 南京理工大学国家特种超细粉体工程技术研究中心,江苏,南京,210094;无锡肿瘤防治研究所,江苏,无锡 |
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| 基金项目： | 国家自然科学基金
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江苏省自然科学基金 |
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| 摘 要： | 本文采用乳化交联法制备了可附载放射性核素的磁靶向药物载体-磁性壳聚糖复合微球.考察了壳聚糖浓度、Fe3O4/壳聚糖质量比及搅拌速度等因素对磁性壳聚糖微球粒径、粒径分布以及形貌等对复合过程的影响,确定了制备高磁响应性的磁性壳聚糖的最佳条件,并借助不同手段对磁性壳聚糖的粒径、粒径分布、形貌及磁性能进行了初步表征.
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| 关 键 词： | 放射性核素 载体 磁性壳聚糖微球 制备 |
| 文章编号： | 1004-793X(2004)05-0660-03 |
| 修稿时间： | 2003年12月19日 |
Preparation and Characterization of Magnetic Chitosan Microspheres for the Carriers of Radionuclides in Therapy |
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| JIANG Wei ,LI Feng-sheng ,YANG Yi,LIU Hong-ying ,CHU Jiang-jun.Preparation and Characterization of Magnetic Chitosan Microspheres for the Carriers of Radionuclides in Therapy[J].Journal of Materials Science and Engineering,2004,22(5):660-662. |
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| Authors: | JIANG Wei LI Feng-sheng YANG Yi LIU Hong-ying CHU Jiang-jun |
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| Affiliation: | JIANG Wei 1,LI Feng-sheng 1,YANG Yi,LIU Hong-ying 1,CHU Jiang-jun 2 |
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| Abstract: | In this paper, magnetic chitosan microspheres which can load radionuclides were prepared by the suspension cross-linking technique. The results demonstrated that the concentration of chitosan solution, Fe 3O 4/chitosan ratio and stirring rate of the suspension medium were the most effective parameters for the size/size distribution, morphology and magnetism of magnetic chitosan microspheres. Furtherly, the best preparation circuit is optimized. Finally, the size, size distribution, morphology and magnetism were studied by different instruments. |
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| Keywords: | radionuclide carriers magnetic chitosan microspheres preparation |
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