Extractive fermentation for fumaric acid production by Rhizopus oryzae |
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| Authors: | Qing Xu Silong He Ling Jiang Jianping Wen Rongfeng Guan |
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| Affiliation: | 1. Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China;2. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, P.R. China;3. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, P.R. China;4. College of Food Science and Light Industry, Nanjing Tech University, Nanjing, P.R. China;5. Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province, Yancheng Institute of Technology, Yancheng, P.R. China |
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| Abstract: | Low product concentration and high cost of recovery process have motivated the study of in situ removal of fumaric acid from fermentation broth. After a series of screenings, an integrated process with fumaric acid fermentation and extraction was developed. Under this integrated process, fumaric acid production and productivity increased from 18.06 g/L to 34.23 g/L, and from 0.27 g/L/h to 0.57 g/L/h, respectively. Neutralizing agent utilization decreased by 58.75%, and 140.7 g/L ammonium fumarate was obtained after back extraction, which could be directed used to produce related derivatives without concentration. Thus, the integrated process was more economic and environmental friendly. |
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| Keywords: | Extraction fermentation fumaric acid in situ Rhizopus oryzae |
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