| 锌缺乏与过量的体外致畸效应研究 |
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| 引用本文： | 相大鹏,王瑞淑. 锌缺乏与过量的体外致畸效应研究[J]. 中国食品卫生杂志, 1996, 0(5) |
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| 作者姓名： | 相大鹏 王瑞淑 |
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| 作者单位： | 汕头卫生检疫局(相大鹏)，华西医科大学(王瑞淑) |
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| 摘 要： | 采用大鼠胚胎中脑细胞和肢芽细胞体外微团培养法，研究锌缺乏与过量的致畸性及锌对维生素Ａ致畸作用的影响。结果表明，缺乏锌对中脑细胞和肢芽细胞的分化无特异性抑制作用。缺锌的致畸作用可能是细胞增殖受到抑制而引起的非特异性致畸作用。锌过量既有特异性又有非特异性致畸作用，但高剂量时主要表现为非特异性作用。维生素Ａ的致畸性因加入高剂量锌而加强。
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| 关 键 词： | 锌 致畸剂 体外 维生素A 协同作用 |
Study on the teratogenicity of Zinc-deficiency and Zinc-excess in vitro |
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| Xiang Dapeng,West China University of Medical Science,Chengdu,PRCWang Ruishu. Study on the teratogenicity of Zinc-deficiency and Zinc-excess in vitro[J]. Chinese Journal of Food Hygiene, 1996, 0(5) |
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| Authors: | Xiang Dapeng West China University of Medical Science Chengdu PRCWang Ruishu |
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| Affiliation: | Xiang Dapeng,West China University of Medical Science,610041 Chengdu,PRCWang Ruishu |
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| Abstract: | The teratogensis of Zinc-deficiency and Zinc-excess was studied using the method of micromass culture with rat embryo midbrain and limb bud cells. The results showed that Zinc-deficiency could not specifically inhibit the differentiation of rat midbrain or limb bud cells, maybe the teratogenicity of it resulted from cell survival being inhibited and be nonspecific. Zinc-excess has both specific and nonspecific teratogenicity. At the high concentration it is mainly nonspecific effect and the teratogenicity of Vit A is enhanced. |
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| Keywords: | Zinc teratogen in vitro vitamin A synergistic action |
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