羟基磷灰石-二氧化锆生物复合材料的制备及其生物相容性

对适用于人体承重部位的人工种植体羟基磷灰石2二氧化锆生物复合材料的制备工艺、微观结构及生物相容性进行了初步研究。用扫描电镜(SEM) 、X 射线衍射(XRD) 和透射电镜( TEM) 对粉体和复合材料进行分析。用体外检测复合材料浸提液对健康青年人末梢血单个核细胞( PBMC) 的激活来评价其免疫相容性。结果表明:1600 ℃无压烧结3h 后的复合材料表面层主晶相为β-Ca₃ ( PO₄ )₂ (β-TCP) 、α-Ca₃ ( PO₄ )₂ (α-TCP) 和CaZrO₃ 相。单纯复合材料和梯度复合材料的表面粗糙度分别为3. 12μm 和1. 95μm。其弯曲强度分别为732. 85 MPa 和689.04 MPa 。HA/ ZrO₂ 复合材料具有免疫相容性, 梯度复合材料的免疫相容性优于单纯复合材料。

Preparation and biocompatibil ity of hydroxylapatite-zirconia biocomposite

The preparation , microst ructure and biocompatibility were studied for the hydroxylapatite-zirconia( HA/ ZrO2 ) biocomposite applied to artificial implant s of human load-bearing part s. XRD , SEM and TEM wereused to analyse the powders and composite. In order to evaluate the immunocompatibility of the composite , it sext ract was picked up to activate the peripheral blood mononuclear cells ( PBMCs) donated by healthy young peoplein vit ro. The result s show that the major phases of the compositeps surface layer areβ- andα-tricalcium phosphate (β- ,α-TCP) and CaZrO3 af ter being sintered at 1600 ℃for 3 hours. The surface roughness of the simplicial compositeand graded composite is 3. 12μm and 1. 95μm respectively. Their tensile st rength is 732. 85 MPa and 689. 04 MParespectively. The composite has immunocompatibility , whereas the immunocompatibility of the graded composite isbetter than that of the simplicial composite.