| 新型药物载体材料——端羟基聚(丙交酯-co-对二氧环己酮)的合成与表征 |
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| 引用本文： | 王素军,罗彦凤,刘钊,黄美娜,王远亮. 新型药物载体材料——端羟基聚(丙交酯-co-对二氧环己酮)的合成与表征[J]. 功能材料, 2009, 40(11) |
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| 作者姓名： | 王素军 罗彦凤 刘钊 黄美娜 王远亮 |
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| 作者单位： | 重庆大学,生物工程学院,"生物流变科学与技术"教育部重点实验室,生物材料与仿生工程中心,重庆,400030 |
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| 基金项目： | 国家科技支撑计划，重庆市科技攻关重点项目 |
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| 摘 要： | 聚乳酸(PLA)作为药物载体材料存在因疏水性强而导致的药物释放速率难控以及在循环系统中停留时间短等问题.研究表明,在PLA中引入乙醇酸(GA)可提高材料降解速率,引入聚乙二醇(PEG)则可延长共聚物在循环系统中的停留时间.研究以丙交酯(LA)和对二氧环己酮(PDO)为主要原料,在辛酸亚锡-乙二醇共引发体系的存在下,通过熔融开环聚合制备出了端羟基聚(丙交酯-co-对二氧环己酮)(HO-P(LA-co-PDO)-OH).这种同时具有PLA、GA和EG结构单元的大分子二醇可望成为一种降解速率可控、在循环系统中停留时间可调的新型药物载体材料.采用DSC、~1H NMR、~(13)C NMR和GPC-MALLs等对其结构和热学性能进行了表征.分子量检测结果表明,HO-P(LA-co-PDO)-OH的分子量随原料中PDO/LA摩尔比的减小而增大.
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| 关 键 词： | 丙交酯 对二氧环己酮 共引发体系 药物载体 |
Synthesis and characterization of a novel drug carrier material |
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| WANG Su-jun,LUO Yan-feng,LIU Zhao,HUANG Mei-na,WANG Yuan-liang. Synthesis and characterization of a novel drug carrier material[J]. Journal of Functional Materials, 2009, 40(11) |
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| Authors: | WANG Su-jun LUO Yan-feng LIU Zhao HUANG Mei-na WANG Yuan-liang |
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| Affiliation: | WANG Su-jun,LUO Yan-feng,LIU Zhao,HUANG Mei-na,WANG Yuan-liang(Key Laboratory of Biorheological Science and Technology,Ministry of Education,Bioengineering College,Chongqing University,Research Center of Bioinspired Material Science and Engineering,Chongqing 400030,China) |
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| Abstract: | The incorporation of glycolic acid (GA) into polylactic acid (PLA) resulted in fastened and controllable degradation rate of the obtained copolymer,and the copolymerization of poly(ethylene glycol) (PEG) with PLA produced block copolymers exhibiting extended residence time in circulation systems. In this study,p-dioxanone (PDO) was employed to copolymerize with DL-lactide (LA) via ring-opening melt polymerization using Sn(Oct)2 as an initiator and ethylene glycol as a co-initiator. The obtained hydroxyl-ter... |
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| Keywords: | lactide p-dioxanone co-initiator system drug carrier |
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