手性拆分液膜及固膜的研究进展

对外消旋体的手性拆分是获得单-对映体的有效途径,在诸多拆分方法中,膜拆分法以其能耗低、易连续操作,易工业放大的优点受到广泛关注,被认为是最有前途的方法.本文将膜技术分为液膜和固膜两部分,分别介绍了两者在手性物质拆分中的研究进展,并总结了各种方法的优缺点,在此基础上提出了存在的问题和今后的研究方向.

Development of membranes for chiral resolution

Raceme resolution is the main route to get pure enantiomer.Among all kinds of the resolution methods,membrane resolution methods are considered as the most promising ones because of their special advantages,such as low energy consumption,continuous operation mode and convenient up-scaling and so on.In this paper,we consider membrane as two parts:liquid membranes and solid membranes,and introduce their development in chiral resolution respectively.The advantages and disadvantages of each method are also summarized.Moreover,the problems which need to be resolved and the trend of development are discussed.