Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases |
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Authors: | Jorge Sanz-Ros,Cristina Mas-Bargues,Nekane Romero-Garcí a,Javier Huete-Acevedo,Mar Dromant,Consuelo Borrá s |
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Affiliation: | 1.Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, 46010 Valencia, Spain;2.Cardiology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain |
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Abstract: | Aging is associated with an alteration of intercellular communication. These changes in the extracellular environment contribute to the aging phenotype and have been linked to different aging-related diseases. Extracellular vesicles (EVs) are factors that mediate the transmission of signaling molecules between cells. In the aging field, these EVs have been shown to regulate important aging processes, such as oxidative stress or senescence, both in vivo and in vitro. EVs from healthy cells, particularly those coming from stem cells (SCs), have been described as potential effectors of the regenerative potential of SCs. Many studies with different animal models have shown promising results in the field of regenerative medicine. EVs are now viewed as a potential cell-free therapy for tissue damage and several diseases. Here we propose EVs as regulators of the aging process, with an important role in tissue regeneration and a raising therapy for age-related diseases. |
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Keywords: | intercellular communication extracellular vesicles stem cells age-related diseases |
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