| 4-氯喹唑啉类化合物的合成 |
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| 引用本文： | 戴佳亮,洪一鸣,熊杰,何小飞,沈振陆,莫卫民.4-氯喹唑啉类化合物的合成[J].浙江化工,2011,42(8):4-6,9. |
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| 作者姓名： | 戴佳亮 洪一鸣 熊杰 何小飞 沈振陆 莫卫民 |
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| 作者单位： | 浙江工业大学化学工程与材料学院,浙江杭州,310014 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 以邻氨基苯甲酸类化合物和醋酸脒为原料，经环合反应得到喹唑啉-4（3H）-酮类化合物，再经POCl3氯化后得到4-氯喹唑啉类化合物。所得化合物的结构均经核磁和质谱确证。
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| 关 键 词： | 4-氯喹唑啉 氯化 邻氨基苯甲酸 喹唑啉-4（3H）-酮 |
Synthesis of 4-Chloroquinazoline Derivatives |
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| DAI Jia-liang,HONG Yi-ming,XIONG Jie,HE Xiao-fei,SHEN Zhen-lu,MO Wei-min.Synthesis of 4-Chloroquinazoline Derivatives[J].Zhejiang Chemical Industry,2011,42(8):4-6,9. |
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| Authors: | DAI Jia-liang HONG Yi-ming XIONG Jie HE Xiao-fei SHEN Zhen-lu MO Wei-min |
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| Affiliation: | DAI Jia-liang,HONG Yi-ming,XIONG Jie,HE Xiao-fei,SHEN Zhen-lu,MO Wei-min(College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Hangzhou 310014,China) |
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| Abstract: | Quinazolin-4 （3H）-ones were conveniently synthesized from anthranilie acids and amidines via cyclization reaction, which could be chloridized with POCl3 to obtain 4-chloroquinazoline derivatives. The structures of the products were characterized by 1HNMR and MS. |
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| Keywords: | 4-chloroquinazoline chlorination anthranilic acid quinazolin-4（3H）-one |
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