Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer |
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| Authors: | Carolina Maria Sassu Innocenza Palaia Serena Maria Boccia Giuseppe Caruso Giorgia Perniola Federica Tomao Violante Di Donato Angela Musella Ludovico Muzii |
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| Affiliation: | Department of Maternal and Child Health and Urological Sciences, “Sapienza” University of Rome, Polyclinic Umberto I, 00161 Rome, Italy; (C.M.S.); (S.M.B.); (G.C.); (G.P.); (F.T.); (V.D.D.); (A.M.); (L.M.) |
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| Abstract: | Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these challenging patients. Currently, most data can be obtained from tumor biopsy samples, but this is not always available and implies a surgical procedure. On the other hand, circulating biomarkers are detected with non-invasive methods, although this might require expensive techniques. Given the fervent hope in their value, here we focused on the most studied circulating biomarkers that could play a role in PtR OC. |
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| Keywords: | platinum-resistant ovarian cancer circulating biomarker liquid biopsy prognosis drug response biomarker |
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