脂肪醇类溶剂对青霉素的萃取

研究了不同醇类及醇酯混合体系对青霉素的萃取. 在pH=4的条件下脂肪醇及醇酯混合体系的萃取能力均高于乙酸丁酯. 具有相同碳原子数、带支链的脂肪醇对青霉素的萃取能力比直链醇强，平衡后的有机相水含量下降. 红外光谱分析表明：乙酸丁酯的加入使脂肪醇羟基谱带变宽且明显向高波数方向位移，能阻止醇的多聚，使羟基活性增强. 激光拉曼光谱结果证明：青霉素是以反相微乳液的形式进入脂肪醇相的；支链的存在使体系的有序性和极性都明显增加.

Investigation on Extraction of Penicillin by Aliphatic Alcohols

Extracting penicillin by aliphatic alcohols was studied in this work. The aliphatic alcohols were more efficient than butyl acetate in extracting penicillin at pH=4. Mixtures of aliphatic alcohol and butyl acetate showed strong coordinated extraction effect. Aliphatic alcohols with branched chain had a little stronger ability to extracting penicillin than straight chain alcohols with the same number of carbon atoms, and water content in organic phase was reduced at the same time. Results of FT-IR indicated, that with adding of butyl acetate, hydroxyl group spectra of aliphatic alcohol became wider and shifted to higher wavenumber. It suggested that butyl acetate molecular blocked forming of aliphatic alcohol congeries, which made hydroxyl group more active. It was suggested by FT-Raman that penicillin molecule entered alcohol phase in inverse microemulsion. The branched chain of alcohols made the system more orderly and polar, which was also favorable to extraction of penicillin.