新型纳米材料与噬菌体展示技术在真菌毒素检测中的应用

真菌毒素是真菌在生长繁殖过程中产生的次级有毒代谢产物,具有致癌、致畸、致突变的毒性作用,严重危害人体健康,因此对其检测与控制非常重要.现有检测方法普遍存在样品预处理复杂、成本高、操作繁琐等缺点,且会对操作人员和环境造成潜在二次危害.新型纳米材料可以提高真菌毒素的检测灵敏度,噬菌体展示技术可以筛选真菌毒素的模拟表位和抗真...

Application of new nanomaterials and phage display technology in mycotoxin detection

Mycotoxins are toxic secondary metabolites produced by some fungi during growth and reproduction.They have carcinogenic,teratogenic and mutagenic effects,which seriously endanger human health.Therefore,their detection and control are of great importance.However,the existing detection methods generally have the disadvantages of complex sample pretreatment,high cost and cumbersome operation,and may cause potential secondary hazards to operators and the environment.The detection sensitivity of mycotoxins can be improved with new nanomaterials,and the mimic epitopes of mycotoxins and the recombinant antibodies against mycotoxins can be screened through phage display technology,hence reducing the detection cost and achieving the purpose of non-toxic detection.The recent application of different nanomaterials and phage display technology and their combination in mycotoxin detection were reviewed,and the future development is prospected.