Optimizing the mechanical properties of electrospun polycaprolactone and nanohydroxyapatite composite nanofibers |
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| Authors: | A. Doustgani E. Vasheghani-Farahani M. Soleimani S. Hashemi-Najafabadi |
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| Affiliation: | 1. Biotechnology Group, Chemical Engineering Department, Tarbiat Modares University, Tehran, Iran;2. Department of Hematology, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran;1. NanoBioMat, Federal University of Santa Catarina, 88040-900 Florianópolis, Brazil;2. NanoScoping, 88040-400 Florianópolis, Brazil;1. National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, PR China;2. Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, PR China;1. Sabanci University Nanotechnology Research and Application Center, 34956 Tuzla, Istanbul, Turkey;2. Faculty of Engineering and Natural Science, Sabanci University, 34956 Tuzla, Istanbul, Turkey;3. Center of Excellence for Functional Surfaces and Interfaces for Nano-Diagnostics (EFSUN), Sabanci University, Orhanli, 34956 Tuzla, Istanbul, Turkey;4. Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, SE-141 57 Stockholm, Sweden |
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| Abstract: | Interest in fabrication of nanofibers using electrospinning has recently increased due to the ability to produce fibers with controlled structures, orientations, and dimensions. Tensile properties of electrospun fibers have not been widely investigated due to the difficulties in handling nanofibers and measuring low load for deformation. In this study, the effects of process parameters on the mechanical properties of electrospun composite nanofibers of polycaprolactone and nanohydroxyapatite were experimentally investigated. Response surface methodology (RSM) was utilized to design the experiments at the settings of solution concentration, voltage, spinning distance and flow rate. Mechanical properties of the electrospun fibers were correlated with these variables using a third order polynomial function. It was found that polymer concentration, voltage and spinning distance were the most effective parameters. The predicted mechanical properties were in good agreement with the experimental results. |
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