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Cloning and functional analysis of cis-prenyltransferase from Thermobifida fusca |
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| Authors: | Takanori Ambo Motoyoshi Noike Hirofumi Kurokawa Tanetoshi Koyama |
| Affiliation: | aInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira 2-1-1, Aoba-ku, Sendai 980-8577, Japan |
| Abstract: | cis-Prenyltransferase catalyzes the synthesis of Z,E-mixed prenyl diphosphates by a condensation of isopentenyl diphosphate to an allylic diphosphate. A novel gene encoding a cis-prenyltransferase is cloned from Thermobifida fusca. It showed a unique substrate specificity accepting dimethylallyl diphosphate as a shortest allylic substrate, and synthesizes polyprenyl products up to C70. |
| Keywords: | Sugar carrier lipid biosynthesis Prenyltransferase Thermobifida fusca Actinomycete Isoprenoid biosynthesis |
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