| 2-氨基-4-异丙基-5-溴苯甲酸的合成 |
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| 引用本文： | 蔡亚祥,位军辉,徐建康,朱国良,车大庆.2-氨基-4-异丙基-5-溴苯甲酸的合成[J].广州化工,2012,40(9):77-78. |
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| 作者姓名： | 蔡亚祥 位军辉 徐建康 朱国良 车大庆 |
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| 作者单位： | 浙江九洲药业股份有限公司研发中心,浙江台州,318000 |
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| 摘 要： | 以间异丙基苯胺为起始原料,与水合氯醛、盐酸羟胺反应后,经Sandmeyer法环合、溴化、氧化得到目标化合物2-氨基-5-溴-4-异丙基苯甲酸。目标化合物的结构经红外光谱、1H NMR和MS确证。该合成方法具有原料易得,合成路线短,操作简单,生产成本低廉的优点,总收率由文献报道的28%提高到39%,更适合工业化生产。
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| 关 键 词： | 2-氨基-4-异丙基-5-溴苯甲酸 间异丙基苯胺 环合 溴化 氧化 合成 |
The Synthesis of 2 - Amino - 4 - Isopropyl - 5 - Bromobenzoic Acid |
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| CAI Ya-xiang,WEI Jun-hui,XU Jian-kang,ZHU Guo-liang,CHE Da-qing.The Synthesis of 2 - Amino - 4 - Isopropyl - 5 - Bromobenzoic Acid[J].GuangZhou Chemical Industry and Technology,2012,40(9):77-78. |
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| Authors: | CAI Ya-xiang WEI Jun-hui XU Jian-kang ZHU Guo-liang CHE Da-qing |
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| Affiliation: | CAI Ya - xiang , WEI Jun - hui , XU Jian - kang , ZHU Guo - liang , CHE Da - qing (R＆D Center, Zhejiang Jiuzhou Pharmaceutical Co., Ltd., Zhejiang Taizhou 318000, China) |
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| Abstract: | The target compound of 2 -amino -4 -isopropyl -5 -bromobenzoic acid was synthesized from misoprop- ylaniline by reaction with chlora hydrate/hydroxylamine hydrochloride and then by cyclization of Sandmeyer method, bromination and oxidation, the structure of the target compound was confirmed by IR, 1H - NMR and MS. The synthetic procedure was suitable for industrial production for the advantage of avaible materials, shorter routes, convenient operation and lower cost, the overall yield was improved from the reported 28% to 39%. |
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| Keywords: | 2 - amino - 4 - isopropyl - 5 - bromobenzoic acid m - isopropylaniline cyclization bromination oxi- dation synthesis |
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