惰性金属催化不对称硫醚氧化

药物中多数使用的为低于50个原子组成的有机小分子,这些小分子中很多具有手性,药理作用是药物小分子通过与体内大分子之间严格手性匹配识别实现的。手性亚砜作为重要的手性中间体、手性配体、辅剂、催化剂和手性药物,光学纯度的手性亚砜是很多药物的活性基团,所以对潜手性的硫醚的不对称催化氧化以达到高光学纯度是具备重大意义的。本文对钛催化硫醚氧化及其相关体系作简要的介绍,然后再进一步介绍亚砜作为药物方面的应用。

The Oxidation of Chiral Sulfoxides Catalyzed by Inert Metals

Most of the drugs included less than 50 atoms among those small organic molecules, which had a large part of chirality. The pharmacology chiral sulfoxides strictly matched large molecules to realize its fuction. Chiral sulfox- ides was the important chiral intermediate, chiral ligands, auxiliary agents, catalysts and chiral drugs, so the high enanti- oselectivity sulfide oxidation meaned a lot. The progress of titanium - catalyzed enantioselective sulfide oxidation, and the application of chiral sulfoxide used medicines were introduced.