Drug Release Properties of the Microcapsules of Adriamycin Hydrochloride with Ethylcellulose Prepared by a Phase Separation Technique |
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Authors: | Y Kawashima S Y Lin A Kasai H Takenaka K Matsunami Y Nochida H Hirose |
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Affiliation: |
a Gifu College of Pharmacy, Gifu, JAPAN
b Gifu Prefecture Hospital, Gifu, JAPAN
c Department of Medicine, Gifu University, Gifu, JAPAN |
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Abstract: | Adriamycin hydrochloride was microencapsulated with ethylcellulose by a phase separation method to develop a prolonged release dosage form. Polyisobutylene (PIB) was used as a coacervation-inducing agent to control the particle size and drug release rate of the resultant microcapsules. With increasing the concentration of PIB (1 to 3 %) the average diameter of the microcapsules decreased, due to the fact that the microcapsules were discreted to a single microcapsule. At low concentration of PIB, the resultant microcapsules were agglomerated, which resulted in increasing the size. The microcapsules prepared with PIB 2 % prolonged desirably the drug release from the microcapsules. A little size effects of the microcapsules on the drug release rate was found for the microcapsules with PIB 2 % and 3 %. |
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