Interleukin-15 Affects Differentiation and Apoptosis in Adipocytes: Implications in Obesity |
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Authors: | Gemma Fuster Vanessa Almendro Cibely Cristine Fontes-Oliveira Míriam Toledo Paola Costelli Sílvia Busquets Francisco J López-Soriano Josep M Argilés |
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Affiliation: | 1.Departament de Bioquímica i Biologia Molecular, Facultat de Biologia,Cancer Research Group, Universitat de Barcelona,Barcelona,Spain;2.Institut de Biomedicina de la Universitat de Barcelona (IBUB),Barcelona,Spain;3.Dipartimento di Medicina e Oncologia Sperimentale,Università di Torino,Torino,Italy |
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Abstract: | Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as
a regulator of energy homeostasis. In this study, we analyzed the effects of IL-15 on adipocyte differentiation using the
3T3-L1 preadipose cell line. The data show that IL-15 tends to reduce the rate of adipocyte proliferation, induces apoptosis,
and partially stops differentiation. The signaling molecules behind these actions of the cytokine on adipose cells are: p42/p44
MAPK (which seem to be associated with the reduced rate of proliferation induced by the cytokine), STAT5 (which is related
to the actions of IL-15 on differentiation), and SAPK/JNK (which are related to the increased apoptosis induced by IL-15).
In conclusion, using the 3T3-L1 adipocyte cell line, the results presented here show that IL-15 exerts important effects on
differentiation, proliferation and apoptosis. Altogether, the results presented here reinforce the idea that IL-15 is an important
mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves
additional studies. |
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