BTN1, a Yeast Gene Corresponding to the Human Gene Responsible for Batten's Disease,is Not Essential for Viability,Mitochondrial Function,or Degradation of Mitochondrial ATP Synthase |
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Authors: | DAVID A PEARCE FRED SHERMAN |
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Abstract: | The Saccharomyces cerevisiae gene BTN1, encodes a 408 amino acid putative integral membrane protein, which is 39% identical and 59% similar to the human Cln3p, whose mutant forms are responsible for Batten's disease and for a diminished degradation of mitochondrial ATPase synthase subunit c. Disruption experiments established that Btn1p is not essential for viability, mitochondrial function, or degradation of mitochondrial ATP synthase in yeast. © 1997 John Wiley & Sons, Ltd. |
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Keywords: | Batten's disease ATP synthase degradation mitochondria Saccharomyces cerevisiae |
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