The Role of Mitochondrial Abnormalities in Diabetic Cardiomyopathy |
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Authors: | Siarhei A. Dabravolski Nikolay K. Sadykhov Andrey G. Kartuesov Evgeny E. Borisov Vasily N. Sukhorukov Alexander N. Orekhov |
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Affiliation: | 1.Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine [UO VGAVM], 7/11 Dovatora Str., 210026 Vitebsk, Belarus;2.Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia; (N.K.S.); (A.G.K.);3.Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, 119991 Moscow, Russia; (E.E.B.); (V.N.S.);4.Institute for Atherosclerosis Research, Osennyaya 4-1-207, 121609 Moscow, Russia; |
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Abstract: | Diabetic cardiomyopathy (DCM) is defined as the presence in diabetic patients of abnormal cardiac structure and performance (such as left ventricular hypertrophy, fibrosis, and arrhythmia) in the absence of other cardiac risk factors (such as hypertension or coronary artery disease). Although the pathogenesis of DCM remains unclear currently, mitochondrial structural and functional dysfunctions are recognised as a central player in the DCM development. In this review, we focus on the role of mitochondrial dynamics, biogenesis and mitophagy, Ca2+ metabolism and bioenergetics in the DCM development and progression. Based on the crucial role of mitochondria in DCM, application of mitochondria-targeting therapies could be effective strategies to slow down the progression of the disease. |
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Keywords: | diabetic cardiomyopathy diabetes mellitus mitophagy bioenergetics Ca2+ metabolism |
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