Roles of Keratins in Intestine |
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Authors: | Jeongwon Mun Whan Hur Nam-On Ku |
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Affiliation: | 1.Department of Bio-Convergence ISED, Underwood International College, Yonsei University, Seoul 03722, Korea; (J.M.); (W.H.);2.Interdisciplinary Program of Integrated OMICS for Biomedical Sciences, Yonsei University, Seoul 03722, Korea |
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Abstract: | Keratins make up a major portion of epithelial intermediate filament proteins. The widely diverse keratins are found in both the small and large intestines. The human intestine mainly expresses keratins 8, 18, 19, and 20. Many of the common roles of keratins are for the integrity and stability of the epithelial cells. The keratins also protect the cells and tissue from stress and are biomarkers for some diseases in the organs. Although an increasing number of studies have been performed regarding keratins, the roles of keratin in the intestine have not yet been fully understood. This review focuses on discussing the roles of keratins in the intestine. Diverse studies utilizing mouse models and samples from patients with intestinal diseases in the search for the association of keratin in intestinal diseases have been summarized. |
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Keywords: | keratin intestine IBD CRC transgenic mice |
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