| 水溶液的冷冻干燥问题(英文) |
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| 引用本文： | 王维,陈墨,陈国华.水溶液的冷冻干燥问题(英文)[J].中国化学工程学报,2012,20(3):551-559. |
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| 作者姓名： | 王维 陈墨 陈国华 |
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| 作者单位： | 1. College of Life Science, Dalian Nationalities University, Dalian 116600, China;2. Department of Chemical Engineering, Dalian University of Technology, Dalian 116024, China;3. Department of Chemical and Biomolecular Engineering, the Hong Kong University of Science and Technology, Hong Kong, China |
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| 基金项目： | Supported by the National Natural Science Foundation of China(21076042);Research Grants Council of Hong Kong SAR (RGC 600704) |
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| 摘 要： | Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry.The increased importance of the process is gaining a worldwide interest of research.A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error empiricism.Formulation and process development need a systematical understanding of the physical chemistry of freezing and freeze drying,material science and mechanisms of heat and mass transfer.This paper presents an overview on freeze drying of aqueous solutions based on publications in the past few decades.The important issues of the process are analyzed.
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| 关 键 词： | desorption eutectic formation excipient glass transition sublimation supercooling |
| 收稿时间： | 2012-03-01 |
Issues in Freeze Drying of Aqueous Solutions |
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| WANG Wei,CHEN Mo,and CHEN Guohua.Issues in Freeze Drying of Aqueous Solutions[J].Chinese Journal of Chemical Engineering,2012,20(3):551-559. |
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| Authors: | WANG Wei CHEN Mo and CHEN Guohua |
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| Affiliation: | 1. College of Life Science, Dalian Nationalities University, Dalian 116600, China;2. Department of Chemical Engineering, Dalian University of Technology, Dalian 116024, China;3. Department of Chemical and Biomolecular Engineering, the Hong Kong University of Science and Technology, Hong Kong, China |
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| Abstract: | Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry.The increased importance of the process is gaining a worldwide interest of research.A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error empiricism.Formulation and process development need a systematical understanding of the physical chemistry of freezing and freeze drying,material science and mechanisms of heat and mass transfer.This paper presents an overview on freeze drying of aqueous solutions based on publications in the past few decades.The important issues of the process are analyzed. |
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| Keywords: | desorption eutectic formation excipient glass transition sublimation supercooling |
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