Optimization of Fermentation Parameters for Higher Lovastatin Production in Red Mold Rice through Co-culture of <Emphasis Type="Italic">Monascus purpureus</Emphasis> and <Emphasis Type="Italic">Monascus ruber</Emphasis> |
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Authors: | Bibhu Prasad Panda Saleem Javed Mohammad Ali |
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Affiliation: | (1) Pharmaceutical Biotechnology Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India;(2) Molecular Biology and Biotechnology Laboratory, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India; |
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Abstract: | Monascus, fermented rice (red mold rice), has been found to reduce the serum total cholesterol and triglyceride due to presence of
lovastatin. Lovastatin acts as an inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. Coculture of Monascus purpureus MTCC 369 and Monascus ruber MTCC 1880 was used to produce red mold rice by solid-state fermentation. Optimization of different fermentation process parameters
such as temperature, fermentation time, inoculum volume, and pH of the solid medium was carried out by Box–Behnken’s factorial
design of response surface methodology to maximize lovastatin concentration in red mold rice. Maximum lovastatin production
of 2.83 mg/g was predicted at 14th day in solid medium under optimized process condition. |
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