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| 牛磺鹅去氧胆酸钠的提取及与鹅去氧胆酸钠的药理作用比较 | |
| 引用本文： | 公瑞煜,张达,吕志良,都丽萍,张立东,李建蓉,乔学亮.牛磺鹅去氧胆酸钠的提取及与鹅去氧胆酸钠的药理作用比较[J].精细化工,2007,24(10):975-978. |
| 作者姓名： | 公瑞煜 张达 吕志良 都丽萍 张立东 李建蓉 乔学亮 |
| 作者单位： | 1. 华中科技大学,同济医学院,药学院,湖北,武汉,430030 2. 华中科技大学,同济医学院,基础医学院,湖北,武汉,430030 3. 华中科技大学,材料学院,湖北,武汉,430074 |
| 基金项目： | 国家自然科学基金 , 华中科技大学校科研和教改项目 , 华中科技大学校科研和教改项目 |
| 摘 要： | 以500 mL鸡胆汁为基本原料,采用沉淀、过滤、减压蒸馏、真空干燥、抽提、重结晶法,制得了7.2 g结合型的牛磺鹅去氧胆酸钠(TCDCANa),以TLC及IR法确定其结构。并将其与鹅去氧胆酸钠(CDCANa)进行镇咳、平喘和祛痰作用对比实验。药理实验结果为:TCDCANa和CDCANa的镇咳作用减咳率分别为(29.1±5.6)%和(18.2±6.8)%;平喘作用解痉率分别为(79.9±22.8)%和(73.3±22.7)%,祛痰作用酚红排泌量分别为(1.601±0.391)μg/mL和(1.029±0.308)μg/mL,TCDCANa与CDCANa间存在显著性差异(P<0.01)。药理实验结果表明,TCDCANa具有明显的镇咳、平喘、祛痰和抗炎作用,其作用强于CDCANa。 |
| 关 键 词： | 鸡胆 牛磺鹅去氧胆酸钠 药理作用 中药现代化技术 |
| 文章编号： | 1003-5214（2007）10-0975-04 |
| 修稿时间： | 2007-02-09 |
Extraction of Sodium Taurochenodeoxycholate and Comparison of Its Pharmacological Effect with Sodium Chenodeoxycholate |
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| GONG Rui-yu,ZHANG Da,L Zhi-liang,DU Li-ping,ZHANG Li-dong,LI Jian-rong,QIAO Xue-liang.Extraction of Sodium Taurochenodeoxycholate and Comparison of Its Pharmacological Effect with Sodium Chenodeoxycholate[J].Fine Chemicals,2007,24(10):975-978. | |
| Authors: | GONG Rui-yu ZHANG Da L Zhi-liang DU Li-ping ZHANG Li-dong LI Jian-rong QIAO Xue-liang |
| Affiliation: | 1. Pharmaceutical School of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China ; 2. Department of Pathogenic Biology of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China ; 3. Department of Material Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074 ,Hubei , China |
| Abstract: | From 500 mL chicken bile,7.2 g sodium taurochenodeoxycholate(TCDCANa) was prepared through deposition,filtration,vacuum distillation,vacuum drying,extraction and recrystallization.Its structure was determined by TLC and IR.Antitussive test,antiasthmatic test and expectorant test were made with TCDCANa and sodium chenodeoxycholate(CDCANa).Pharmacodynamic results gave the antitussive rates of(29.1±5.6)% and(18.2±6.8)%,antispasmodic rates of(79.9±22.8)% and(73.3±22.7)%,and excretion of phenol red(1.601±0.391) μg/mL and(1.029±0.308) μg/mL respectively.There are significant differences in all those tests between TCDCANa and CDCANa(P<0.01).It is proved that TCDCANa has more evident antitussive,antispasmodic and expectorant effects than CDCANa. |
| Keywords: | chicken bile sodium taurochenodeoxycholate pharmacological effect modernization technology of Chinese medicines |
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