| 乙肝血源疫苗免疫持久性及再免疫的效果观察 |
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| 引用本文： | 巩志立,田禾菁,相秀香,徐玉珍,储全胜.乙肝血源疫苗免疫持久性及再免疫的效果观察[J].粉末涂料与涂装,1991(3). |
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| 作者姓名： | 巩志立 田禾菁 相秀香 徐玉珍 储全胜 |
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| 作者单位： | 卫生部北京生物制品研究所 北京100024(巩志立，田禾菁)，青岛市卫生防疫站 青岛266003(相秀香，徐玉珍，储全胜) |
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| 摘 要： | 应用乙肝血源疫苗对乙肝阴性母亲所生婴儿,用10μg 剂量按0、1、2月免疫程序,共免疫108人。3针免疫后1个月抗-HBs 阳性率为96.3%,1年抗-HBs 阳性率为95.2%,4年为83.2%,6年为72.7%。再免疫后抗体回升到98.5%,S/N 值也由6年时的44.28回升到165.17,即升高接近4倍。表明在免疫前 S/N 值<20抗-HBs 反跳水平最高,S/N>50反跳能力差。说明新生儿免疫6年后仍有较好的免疫效果。
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| 关 键 词： | 乙肝疫苗 抗-HBs阳性率 |
Observation of Persisting and Booster Effect Post HB Vaccine Immunization |
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| Gong Zhili National Vaccine and Seram Institute,Beijing.Observation of Persisting and Booster Effect Post HB Vaccine Immunization[J].Chinese Journal of Biologicals,1991(3). |
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| Authors: | Gong Zhili National Vaccine and Seram Institute Beijing |
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| Abstract: | The Newborns who were born to HBsAg negative mothers were immunized with plasma—derived HB vaccine,10 at intervals 0,1,2 month.108 infants rece-ived immunization.Anti-HBs positive rate was 96.3% at 1 month after 3 doses and at1,4,6 years were 95.8%,83.2% and 72.7% respectively.By booster vaccination,anti—HBs rate rose to 98.5%,and S/N value from 44.28 rose to 165.17.When S/Nvalue was less than 20,response level jumped to 10—20 fold,when S/N valuewas more than 50,no increase of S/N value was found,but had 2 fold inc-rease only after booster immunization |
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| Keywords: | Hepatitis B vaccine Anti-HBs positive rate |
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