食品药品来源的CFTR氯离子通道抑制剂的研究进展

CFTR氯离子通道是目前国际上新兴的治疗分泌型腹泻的分子药靶,CFTR抑制剂通过阻断离子通道的过度分泌来治疗腹泻症状。由于其抑制剂极为稀少,因此CFTR抑制剂的筛选工作是相关领域中最基础、最关键的环节。天然产物兼具结构和生物活性的多样性,在新药和先导化合物的发现中起着重要作用,是药物开发的主要来源,而食品药品来源的天然产物更因为对人体安全无毒副作用而倍受青睐。食品药品来源的CFTR氯离子通道抑制剂对于CFTR相关的腹泻等疾病的机理研究和治疗具有重要价值,同时也为天然产物资源用于现代药物发现提供了依据。

Advances in research of CFTR inhibitors extracted from foods and herbal plants

CFTR chloride channel is the molecular drug target for the treatment of secretory diarrhea. Screening CFTR inhibitors is the most important and basic part of anti-diarrheal drug development. The natural products are diversified both in the structure and the biological activity. In the discovery of drugs and leading compounds, natural products play a key role and become the main source of drug development. Natural products from foods and herbal plants are usually safe for low or no toxicity and side-effect in clinic. CFTR inhibitors which source of foods and traditional Chinese medicines are important of study and treatment of CFTR related diseases, as well as providing a basis for the modern drug discovery in the natural product resources.