铁死亡的机制及其在淋巴瘤中的研究进展

淋巴瘤是常见的血液系统恶性肿瘤，对人类健康造成极大的威胁。目前淋巴瘤的治疗方法包括化疗、分子靶向治疗、造血干细胞移植等，但耐药和复发难治仍是待解决的问题。铁死亡是新发现的一种细胞死亡模式，与铁依赖性的脂质过氧化损伤相关。靶向铁死亡为抑制淋巴瘤进展提供了新思路。本文从铁死亡的起始信号、中间事件、效应阶段、防御机制来阐述铁死亡的机制并回顾了铁死亡在淋巴瘤中的研究进展，为铁死亡在淋巴瘤治疗方法的应用方面提供新的思路。

Mechanism of ferroptosis and its research progress in lymphoma

Lymphoma is a common hematological malignant tumor which poses a great threat to human health. Chemotherapy, molecular targeted therapy, and hematopoietic stem cell transplantation constitute the main treatment methods for lymphoma, however, there are still some patients with lymphoma suffer from drug resistance, relapse and refractory. Ferroptosis is a newly discovered mode of programmed cell death, which is related to iron-dependent lipid peroxidation damage. Targeting ferroptosis provides a novel landscape for inhibiting the growth of lymphoma. We reviewed the mechanism of ferroptosis from the initial signals, intermediate events, effect stages, defense mechanisms and summarized the research progress of ferroptosis in lymphoma, providing novel therapeutic targets in the treatment of lymphoma.