| 胆汁酸代谢调节炎症性肠病的作用机制及药物研发 |
| |
| 引用本文： | 段睿潇,赵一帆,叶永娟,刘敏,李强,周永宁. 胆汁酸代谢调节炎症性肠病的作用机制及药物研发[J]. 金属学报, 2022, 27(10): 1171-1181. DOI: 10.12092/j.issn.1009-2501.2022.10.012 |
| |
| 作者姓名： | 段睿潇 赵一帆 叶永娟 刘敏 李强 周永宁 |
| |
| 作者单位： | 1.兰州大学第一临床医学院,兰州 730000,甘肃;;2.兰州大学第一医院消化科,兰州 730000,甘肃;;3.兰州大学第一医院,甘肃省胃肠病重点实验室,兰州 730000,甘肃 |
| |
| 基金项目： | 国家自然科学基金（71964021）;甘肃教育科技创新项目（2019B-019）;兰州大学第一医院院内基金（ldyyyn2018-38） |
| |
| 摘 要： | 炎症性肠病（IBD）是一种慢性复发性肠道炎症性疾病,发病率及非致死性疾病负担在全世界都有累加的趋势,其病因复杂,发病机制目前还未完全明确。胆汁酸（BAs）是胆汁的主要成份,其可通过与胆汁酸受体结合、调节肠道菌群等参与IBD的发生发展。本文着重讨论BAs代谢在IBD发病中的作用机制,以及基于BAs及其相关靶点的药物研发进展,为今后IBD的预防、治疗和预后研究奠定基础。
|
| 关 键 词： | 炎症性肠病 胆汁酸 胆汁酸受体 肠道菌群 靶向药物 |
| 收稿时间： | 2022-06-23 |
| 修稿时间： | 2022-10-12 |
Mechanism of action of bile acid metabolism in regulating inflammatory bowel disease and the research and development of drugs |
| |
| DUAN Ruixiao,ZHAO Yifan,YE Yongjuan,LIU Min,LI Qiang,ZHOU Yongning. Mechanism of action of bile acid metabolism in regulating inflammatory bowel disease and the research and development of drugs[J]. Acta Metallurgica Sinica, 2022, 27(10): 1171-1181. DOI: 10.12092/j.issn.1009-2501.2022.10.012 |
| |
| Authors: | DUAN Ruixiao ZHAO Yifan YE Yongjuan LIU Min LI Qiang ZHOU Yongning |
| |
| Affiliation: | 1. The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu, China;2. The First Hospital of Lanzhou University, Department of Gastroenterology, Lanzhou 730000, Gansu, China;3. The First Hospital of Lanzhou University, Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China |
| |
| Abstract: | Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal inflammatory disease with an increasing incidence and non-fatal disease burden worldwide. The etiology of IBD is complex, and the pathogenesis has not been completely clarified. Bile acids (BAs) are the main components of bile, which can participate in the occurrence and development of IBD by binding to bile acid receptors and regulating intestinal flora. This article focuses on the mechanism of BAs metabolism in the pathogenesis of IBD, and the research and development progress of drugs based on BAs and their related targets, so as to lay a foundation for the prevention, treatment and prognosis of IBD in the future. |
| |
| Keywords: | inflammatory bowel disease bile acid bile acid receptors gastrointestinal microbiome targeted drugs |
|
| 点击此处可从《金属学报》浏览原始摘要信息 |
|
点击此处可从《金属学报》下载全文 |
|
