碘难治性分化型甲状腺癌的最新研究进展

近年来，作为最常见的恶性肿瘤之一，甲状腺癌的发病率曲线明显上升。分化型甲状腺癌经过手术、131I放疗及促甲状腺激素抑制等治疗后，大多数患者总体预后良好。但仍有少部分患者对放射性碘治疗不敏感且有1个或多个癌基因的突变，则成为病情进展快、死亡率高的碘难治性分化型甲状腺癌。应用上述的传统治疗手段难以取得满意疗效，本文综述了碘难治性分化型甲状腺癌的诊断及治疗进展，为尽早识别及早期进行靶向治疗等争取必要的时间。

Advances in the study of iodine-resistant differentiated thyroid cancer

Thyroid cancer is one of the most common malignant tumors. After standardized surgery, selective 131I radiotherapy and gonadotropin suppression therapy, the overall prognosis of most patients with differentiated thyroid cancer is good. However, there are still a small number of patients who are not sensitive to radioactive iodine treatment and have mutations of one or more oncogenes, which become iodine-resistant differentiated thyroid cancer. The application of traditional treatment methods cannot achieve satisfactory efficacy, the disease progresses rapidly and the mortality rate is high. This article reviews the progress in the diagnosis and treatment of iodine-resistant differentiated thyroid cancer in order to obtain the necessary time for early identification and targeted therapy.