| 不同胰高血糖素样肽-1受体激动剂对骨代谢影响的研究进展 |
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| 引用本文： | 李玲玲,张洋洋,白佳,杨虹,杨莹,吕海宏.不同胰高血糖素样肽-1受体激动剂对骨代谢影响的研究进展[J].金属学报,2022,27(11):1315-1320. |
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| 作者姓名： | 李玲玲 张洋洋 白佳 杨虹 杨莹 吕海宏 |
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| 作者单位： | 1.兰州大学第一临床医学院，兰州 730000，甘肃；2兰州大学第一医院内分泌科，兰州 730000，甘肃 |
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| 基金项目： | 甘肃省自然科学基金（21JR1RA080） |
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| 摘 要： | 骨质疏松是2型糖尿病（type 2 diabetes mellitus, T2DM）常见并发症之一，近期研究表明T2DM治疗药物胰高血糖素样肽-1受体激动剂（glucagon-like peptide-1 receptor agonists, GLP-1RAs）可以促进骨形成抑制骨吸收，提示这类降糖药物可能使合并骨质疏松和高骨折风险的T2DM患者获益，但其潜在机制尚不完全清楚，并且不同的GLP-1RAs表现出不同的骨骼效应及分子机制。本文将对几种不同GLP-1RAs对骨代谢的影响进行综述。
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| 关 键 词： | 胰高血糖素样肽-1受体激动剂 糖尿病 骨代谢 骨折风险 |
| 收稿时间： | 2022-07-01 |
| 修稿时间： | 2022-11-18 |
Progress in research on the effects of different glucagon-like peptide-1 receptor agonists on bone metabolism |
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| LI Lingling,ZHANG Yangyang,BAI Jia,YANG Hong,YANG Ying,LV Haihong.Progress in research on the effects of different glucagon-like peptide-1 receptor agonists on bone metabolism[J].Acta Metallurgica Sinica,2022,27(11):1315-1320. |
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| Authors: | LI Lingling ZHANG Yangyang BAI Jia YANG Hong YANG Ying LV Haihong |
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| Affiliation: | 1.The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu, China;2.Department of Endocrinology, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China |
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| Abstract: | Osteoporosis is one of the common complications of type 2 diabetes mellitus (T2DM). Recent studies have shown that glucagon-like peptide-1 receptor agonists (GLP-1RAs) can promote bone formation and inhibit bone resorption, suggesting that this hypoglycemic drugs may benefit T2DM patients with osteoporosis and high fracture risk, but its underlying mechanism is not fully understood, and different GLP-1RAs exhibit different skeletal effects and molecular mechanisms. In this paper, the effects of several GLP-1RAs on bone metabolism are reviewed. |
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| Keywords: | glucagon-like peptide-1 receptor agonists diabetes bone metabolism fracture risk |
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