The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration |
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| Authors: | Carl Randall Harrell Valentin Djonov Vladislav Volarevic |
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| Affiliation: | 1.Regenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL 34684, USA;2.Institute of Anatomy, University of Bern, Baltzerstrasse 2, 3012 Bern, Switzerland;3.Center for Molecular Medicine and Stem Cell Research, Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, 34000 Kragujevac, Serbia |
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| Abstract: | Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory properties and, in juxtacrine and paracrine manner, modulate phenotype and function of all immune cells that participate in tissue repair and regeneration. Additionally, MSCs produce various pro-angiogenic factors and promote neo-vascularization in healing tissues, contributing to their enhanced repair and regeneration. In this review article, we summarized current knowledge about molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration. |
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| Keywords: | mesenchymal stem cells immune cells immunomodulation angiogenesis regeneration |
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