Study of the binding in an aqueous medium of inclusion complexes of several cyclodextrins involving fenoprofen calcium |
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| Authors: | Díaz D Escobar Llanos C M Bernad Bernad M J |
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| Affiliation: | Facultad de Química, Departamento de Química Inorgánica, UNAM, Delegación Coyoacan, México. |
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| Abstract: | Interactions among fenoprofen calcium and alpha-, beta-, gamma- and hydroxypropyl-beta-cyclodextrins (HP-beta-CD) were evaluated in aqueous solution by UV/vis and fluorescence direct spectroscopies and monodimensional (1D) 1H-NMR. Different UV/vis and fluorescence emission spectra were obtained to study the apparent binding constants (K) to define the most appropriate cyclodextrin to form the inclusion complexes (IC). beta-CD and HP-beta-CD clearly fit the magnitude of stability constant data of the complexes to take into account the pharmaceutical technology interest. |
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