Dimethyltin(IV) and palladium(II) complexes derived from 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone: Synthesis,crystal structures and biological evaluation |
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| Affiliation: | 1. Henan Key Laboratory of Polyoxometalates, Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, PR China;2. College of Chemistry and Environment, Henan Institute of Finance and Banking, Zhengzhou 450046, PR China;3. Key Laboratory of Natural Medicines and Immune Engineering, Henan University, Kaifeng 475004, PR China;1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi''an 710127, PR China;2. College of Chemistry and Environmental Engineering, Sichuan University of Science & Engineering, Zigong 643000, PR China;3. Shaanxi Key Laboratory of Comprehensive Utilization of Tailings Resources, College of Chemical Engineering and Modern Materials, Shangluo University, Shangluo 726000, PR China |
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| Abstract: | Two metal complexes [(Me)2Sn(L)(OAc)] (1), and [Pd(L)Cl] (2) based on 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone have been synthesized and structurally characterized. X-ray crystallography reveals that in title compounds, each thiosemicarbazone adopts tridentate NNS manner to coordinate with the metal center, and the metal coordination geometry can be described as a distorted pentagonal bipyramid in 1 and a contorted square-planar in 2, respectively. Growth inhibition assays have indicated that two compounds can effectively inhibit the growth of HepG2 cancer cell lines at micromolar concentrations. In addition, apoptosis mechanisms of 2 on HepG2 cells were further investigated. The results show that 2 can promote the apoptosis of HepG2 cells and the apoptosis is associated with the activation of caspase-3. |
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