| 环丙沙星合成中哌嗪缩合反应的研究 |
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| 引用本文： | 黄强,刘国际,李可娟,班春兰,任保增,雒廷亮.环丙沙星合成中哌嗪缩合反应的研究[J].精细石油化工,2005(2):20-21. |
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| 作者姓名： | 黄强 刘国际 李可娟 班春兰 任保增 雒廷亮 |
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| 作者单位： | 郑州大学化工学院,河南,郑州,450002 |
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| 摘 要： | 以环丙沙星中间体与无水哌嗪为原料经缩合反应制备了环丙沙星.考察了原料用量、反应温度、反应时间等因素对产物收率的影响。最佳工艺条件为:1-环丙基-6-氟-7-氯-1,4-二氢-4-氧代-3-喹啉羧酸/无水哌嗪/三乙胺(摩尔比)=1:1.3:0.0165,反应温度130℃,反应时间7h,收率约为80%。
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| 关 键 词： | 无水哌嗪 1-环丙基-6-氟-7-氯-1 4-二氢-4-氧代-3-喹啉羧酸 环丙沙星 缩合 |
| 修稿时间： | 2004年9月30日 |
STUDY ON THE CONDENSATION REACTION IN SYNTHESIS OF CIPROFLOXACIN |
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| Huang Qiang,Liu Guoji,Li Kejuan,Ban Chunlan,Ren Baozeng,Luo Tingliang.STUDY ON THE CONDENSATION REACTION IN SYNTHESIS OF CIPROFLOXACIN[J].Speciality Petrochemicals,2005(2):20-21. |
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| Authors: | Huang Qiang Liu Guoji Li Kejuan Ban Chunlan Ren Baozeng Luo Tingliang |
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| Abstract: | Ciprofloxacin was synthesized from its intermediate and anhydrous piperazidine by condensation reaction. The influencing factors such as amount of raw materials, reaction temperature, reaction time on the yield of product were studied. The optimum synthetic conditions were found as follows:n (1-cyclopropyl-6-fluoro-7-chloro-1, 4-dihydro-4-oxo-quinoline-3-carboxylic acid)/n (anhydrous piperazine)/n(triethylamine) = 1∶1. 3 ∶0.0165, reaction temperature 130℃, reaction time 7 h, the yield of ciprofloxacin were up to 80%. |
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| Keywords: | anhydrous piperazine 1-cyclopropyl-6-fluoro-7-chloro-1 4-dihydro-4-oxo-quinoline-3-carboxylic acid ciprofloxacin condensation |
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