| 无溶剂微波辅助一锅法合成吡喃并[2,3-c]吡唑衍生物 |
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| 引用本文： | 吴璐璐,岳阳,曹占奇,姜松,高萌璐,樊小改,潘振良. 无溶剂微波辅助一锅法合成吡喃并[2,3-c]吡唑衍生物[J]. 化学试剂, 2021, 43(2): 247-252 |
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| 作者姓名： | 吴璐璐 岳阳 曹占奇 姜松 高萌璐 樊小改 潘振良 |
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| 作者单位： | 河南农业大学理学院,河南郑州450002;河南农业大学理学院,河南郑州450002;河南农业大学理学院,河南郑州450002;河南农业大学理学院,河南郑州450002;河南农业大学理学院,河南郑州450002;河南农业大学理学院,河南郑州450002;河南农业大学理学院,河南郑州450002 |
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| 基金项目： | 河南农业大学自然科学类青年创新基金项目(KJCX2020A19);河南农业大学本科实验室开放创新项目(KF1917);河南农业大学博士启动基金项目(30601333);大学生创新训练计划项目(2019104660)。 |
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| 摘 要： | 绿色、高效、简便的催化多组分一锅法反应符合当前所倡导的"绿色"化学理念,是当今有机化学的研究热点.通过在无溶剂微波辅助条件下,使用廉价易得的KF/A1203催化吡唑啉酮、芳香醛和丙二腈的多组分"一锅法"反应,合成了一系列吡喃并[2,3-c]吡唑衍生物,反应时间为5-10 min,产率为85％-98％.标题化合物的结构经...
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| 关 键 词： | 无溶剂合成 微波辅助合成 一锅法 吡喃并[2,3-c]吡唑衍生物 |
Solvent-free One-pot Synthesis of Pyrano[2,3-c]pyrazole Derivatives under Microwave Irradiation |
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| Affiliation: | (College of Science,Henan Agricultural University,Zhengzhou 450002,China) |
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| Abstract: | The green,efficient and simple catalytic reaction with multi-component one-pot is in line with the current"green"chemical concept,and is now a research hotspot in organic chemistry.KF/Al2O3as a cheap and readily accessible catalyst for the solvent-free synthesis of pyrano[2,3-c]pyrazole derivatives by multi-component one-pot reaction of pyrazolone,aryl aldehydes,malononitrile was described.The reaction time was 5~10 min,the yield ranged from 85%to 98%.The target products were confirmed by nuclear magnetic resonance spectroscopy(NMR)and high resolution mass spectrometry data(HR-MS).Compared with the traditional synthetic methods,the work overcomes the environmental pollution caused by the use of solvent and the inconvenience of stepwise reaction and has the advantages of solvent-free,short reaction time and high yield.The catalyst can be recovered and reused for three cycles without loss of activity. |
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| Keywords: | solvent-free synthesis microwave-assisted synthesis one-pot pyrano[2 3-c]pyrazole derivatives |
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