| 雪松醇的合成应用及其药理作用研究进展 |
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| 引用本文： | 汤陆扬,卢小鸾,杨敏,付阳洋,孙晓霞,彭黔荣,杨培昕. 雪松醇的合成应用及其药理作用研究进展[J]. 化学试剂, 2021, 43(1): 48-54 |
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| 作者姓名： | 汤陆扬 卢小鸾 杨敏 付阳洋 孙晓霞 彭黔荣 杨培昕 |
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| 作者单位： | 贵州大学药学院,贵州贵阳550025;贵州中烟工业有限责任公司技术中心,贵州贵阳550000 |
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| 基金项目： | 国家自然科学基金项目(21562014);贵州中烟科技项目(黔烟工技[2015]8号)。 |
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| 摘 要： | 雪松醇(Cedrol,CE),是一种用途极为广泛的天然倍半萜醇,广泛存在于柏科、杉科及松科等多种植物的挥发油中.研究报道CE存在多种药理作用,包括抗炎镇痛、对心脑血管系统作用、抗肿瘤、促进头发生长、抗菌、抗疟原虫活性等.为拓宽其应用,加速其新药研发进程,有必要对其研究进行总结.通过查阅相关文献,归纳总结了CE的提取与检...
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| 关 键 词： | 雪松醇 提取与检测 合成 药理作用 |
Progress on Synthesis Application and Pharmacological Effects of Cedrol |
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| TANG Lu-yang,LU Xiao-luan,YANG Min,FU Yang-yang,SUN Xiao-xia,PENG Qian-rong,YANG Pei-xin. Progress on Synthesis Application and Pharmacological Effects of Cedrol[J]. Chemical Reagents, 2021, 43(1): 48-54 |
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| Authors: | TANG Lu-yang LU Xiao-luan YANG Min FU Yang-yang SUN Xiao-xia PENG Qian-rong YANG Pei-xin |
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| Affiliation: | (School of Pharmacy,Guizhou University,Guiyang 550025,China;Technical Center of China Tobacco Guizhou Industry Co.,Ltd.,Guiyang 550000,China) |
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| Abstract: | Cedrol(CE),a natural sesquiterpene alcohol with a very wide range of uses,is widely present in the volatile oils of various plants such as Cupressaceae,Taxaneae and Pinaceae.CE has a variety of pharmacological effects,including anti-inflammatory and analgesic effects,effects on the cardiovascular and cerebrovascular systems,anti-tumor,hair growth promotion,antibacterial,and anti-plasmodium activities.In order to broaden its application and accelerate its new drug development process,it is necessary to summarize it.This work summarizes the extraction and detection of CE and its application in synthesis by consulting related literature,discusses the pharmacological effects and possible mechanisms of CE in recent years,and analyzes its future development direction,its application and new drugs R&D provides reference. |
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| Keywords: | cedrol extraction and detection synthesis pharmacological effects |
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