Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat |
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Authors: | Escudero Elizabeth Toldrá Fidel Sentandreu Miguel Angel Nishimura Hitoshi Arihara Keizo |
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Affiliation: | Instituto de agroquímica y Tecnología de Alimentos (CSIC), Paterna, Valencia, Spain. |
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Abstract: | This study investigated the in vivo antihypertensive activity of three novel peptides identified in the in vitro digest of pork meat. These peptides were RPR, KAPVA and PTPVP and all of them showed significant antihypertensive activity after oral administration to spontaneously hypertensive rats, RPR being the peptide with the greatest in vivo activity. To our knowledge, this is the first report showing the in vivo antihypertensive action of the three peptides from nebulin (RPR) and titin (KAPVA and PTPVP), thus confirming their reported in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. These findings suggest that pork meat could constitute a source of bioactive constituents that could be utilized in functional foods or nutraceuticals. |
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Keywords: | Antihypertensive activity Peptide Pork meat Angiotensin I-converting enzyme Spontaneously hypertensive rat |
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