| 克林霉素的结构改造及其生物活性研究 |
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| 引用本文： | 夏万东,赵文辉,汤沸.克林霉素的结构改造及其生物活性研究[J].河北化工,2009,32(9):45-47. |
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| 作者姓名： | 夏万东 赵文辉 汤沸 |
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| 作者单位： | 1. 承德石油高等专科学校,河北承德,067000
2. 齐鲁安替制药,山东济南,250105 |
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| 摘 要： | 通过对克林霉素的结构改造,研究克林霉素衍生物的合成及其生物活性.结合相关文献和实验摸索结果,选择优化合适的合成路线,并通过各种分析方法确证其结构.根据合理药物设计原理,设计合成目标化合物,并研究其生物活性.获得1个克林霉素新衍生物,经光谱证明了结构.克林霉素新衍生物有较好的活性,但克林霉素的结构改造需要进一步研究.
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| 关 键 词： | 克林霉素 衍生物 波谱分析 |
Structural Modification and Bioactivity of Clindamycin |
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| XIA Wan-dong,ZHAO Wen-hui,TANG Fei.Structural Modification and Bioactivity of Clindamycin[J].Hebei Chemical Engineering and Industry,2009,32(9):45-47. |
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| Authors: | XIA Wan-dong ZHAO Wen-hui TANG Fei |
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| Affiliation: | 1.Chengde Petroleum College;Chengde 067000;China;2.Qilu Antibiotics Pharmaceutical Co.Ltd;Jinan 250105;China |
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| Abstract: | Study the synthetic process and bioactivities of derivatives of clidamycin by modifying structure of clidamycin.According to rational drug design principle,a series of clidamycin analogues were prepared,and their bioactivities were tested.One new compound was syntheized and confirmed by spectra.Some compounds show better activities,and modification of clidamycin should be worthy to be studied further. |
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| Keywords: | clindamycin deritive spectral analysis |
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