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金纳米颗粒在疾病诊断和食品检测领域的研究进展
引用本文:曹丰晶,胡玉才,王卓,张伟,蒋兴宇.金纳米颗粒在疾病诊断和食品检测领域的研究进展[J].中国材料进展,2012,31(6):31-35,55.
作者姓名:曹丰晶  胡玉才  王卓  张伟  蒋兴宇
作者单位:1. 鲁东大学,山东烟台264025 国家纳米科学中心,北京100190
2. 鲁东大学,山东烟台,264025
3. 国家纳米科学中心,北京,100190
基金项目:国家自然科学基金资助项目,科技部973计划项目
摘    要:纳米科技的发展使纳米在各个领域得到了广泛的应用。由于金纳米颗粒具有较高的摩尔吸光系数和特殊的光学、电学、磁学性质,因此它在化学、生物传感、疾病诊断和食品检测等领域的应用取得了突出进展。综述了最近几年金纳米颗粒在疾病诊断和食品检测领域的最新研究进展,特别介绍了国家纳米科学中心近期的研究结果,他们重点研发了可控功能化纳米材料的合成和应用,构建了便携式、高灵敏度的生物化学分析方法系列,为HIV和阿尔茨海默等重大疾病的诊断提供了新方法。讨论了金纳米颗粒具有的优势及存在的问题,并对其未来的发展进行了展望。

关 键 词:金纳米颗粒  疾病诊断  免疫标记  食品检测  层析法  试纸条

Research Progress of Gold Nanoparticle in Disease Diagnosis and Food Detection
Authors:CAO Fengjing  HU Yucai  WANG Zhuo  ZHANG Wei  JIANG Xingyu
Affiliation:1.Ludong University,Yantai 264025,China)(2.National Center for Nanoscience and Nanotechnology,Beijing 100190,China)
Abstract:The rapid advancement of nanotechnology in recent years has resulted widespread application of nanoparticles.Gold nanoparticles have high extinction coefficients and unique optical and electromagnetic,properties,it has been widely used in improving the sensitivity of the biosensor.It is suitable to be used in different fields including disease diagnosis and assays for ensuring the quality of food.A special presentation on the recent findings of the National Center for Nanoscience,focused on developing synthesis and applications of controllable and functional gold nanomaterials,to build a potable high-sensitivity and visualizable biochemical analysis methods series,offers a new method for the diagnosis of major diseases such as HIV and Alzheimer’s disease.The biologic negative effects and the future development of gold nanoparticles are also discussed here.
Keywords:gold nanoparticles  disease diagnosis  food detection  immune label  Lateral flow test  test strip
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