| 造血细胞发育调控机制的研究进展 |
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| 引用本文： | 陈晓萍,徐作武,姜薇. 造血细胞发育调控机制的研究进展[J]. 浙江工业大学学报, 2007, 35(1): 6-9,21 |
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| 作者姓名： | 陈晓萍 徐作武 姜薇 |
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| 作者单位： | 浙江工业大学,生物与环境工程学院,浙江,杭州,310032 |
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| 摘 要： | 造血发育调控是干细胞研究领域的重要内容,涉及多个层次.它在骨髓局部发生,构成特定的造血微环境.调节因子数量众多,包括细胞因子,趋化因子,粘附因子和细胞外基质中的一些介导分子.造血细胞在调节因子趋导下分别向多个系列定向发育.HOX基因,GATA基因,C/EBP基因等基因家族在不同系列发生特异性的差异表达,这成为造血细胞发育分化的本质性变化.两条主要的细胞信号转导通路,JAK-STAT通路和MAPK通路,介导调节调节因子对造血相关基因的活性调控.上述因素的复杂组合,构成调控网络,最终造成造血细胞的发育分化.
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| 关 键 词： | 造血细胞 骨髓微环境 造血相关基因 JAK-STAT通路 MAPK通路 |
| 文章编号： | 1006-4303（2007）01-0006-04 |
| 修稿时间： | 2006-03-31 |
Advance of regulation mechanism in hematopoietic development |
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| CHEN Xiao-ping,XU Zuo-wu,JIANG Wei. Advance of regulation mechanism in hematopoietic development[J]. Journal of Zhejiang University of Technology, 2007, 35(1): 6-9,21 |
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| Authors: | CHEN Xiao-ping XU Zuo-wu JIANG Wei |
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| Abstract: | Regulation of hematopoietic development is an important part of stem cell research.It occurs at bone marrow and constitutes hematopoietic micro-environment.There are numerous regulators including cytokines,chemokines,adhesions and transductors of hematopoietic cells involving development and differential procession into special systems induced by these regulators.HOX gene,GATA gene,C/EBP gene and some other gene families express in a characteristic way.Two important cell signal pathways,JAK-STAT pathway and MAPK pathway,transfer the signals between regulators and hematopoietic relative genes.The combined factors constitute a regulating net. |
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| Keywords: | hematopoietic cell micro-environment hematopoietic-relative gene JAK-STAT pathway MAPK pathway |
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