Biological fluid interaction with controlled surface properties of organic micro-fluidic devices |
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Authors: | Marshal Dhayal Jeong Sik Choi |
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Affiliation: | a Biological Research Center of Industrial Accelerators, 252 Daeho-dong, Naju, South Korea b Center of Optical Micro Device Systems, Dongshin University, 252 Daeho-dong, Naju, South Korea |
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Abstract: | An organic micro-fluidic device (O-MFD) on silicon/glass substrate was fabricated using plasma polymerisation of acrylic acid (ppAc) with optical lithography including wet and dry etching techniques. The surface chemistry of O-MFD was controlled by depositing ppAc films on MFD. The results showed that these surfaces have more than 50% retention of original monomer functionalities (-COOX) with significant concentration of CO and C-OX at the surface. The water fluid velocity in 100 μm wide and 100 μm deep micro-channels of ppAc deposited O-MFD was increased by a factor of 10 relatively uncoated surfaces. The mixing of 10% of blood in the water has showed a decrease of about 100 μm/s in the fluid velocity relative to water and 10% red colour dye mixed water. The decrease in the fluid velocity of blood mixed water showed the possibility of blood cells interaction with the highly functional ppAc surfaces of micro-channel in O-MFD and that could have advantages in biological fluids (such as protein) separation. |
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Keywords: | Plasma polymerisation Bio-MEMS Micro-fluidics Acrylic acid Bonding |
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