Vascular endothelial growth factor: An important molecular target of curcumin |
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| Authors: | Maryam Saberi-Karimian Niki Katsiki Michele Caraglia Mariarosaria Boccellino Muhammed Majeed |
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| Affiliation: | 1. Student Research Committee, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece;3. Department of Biochemistry, Biophysics and General Pathology, University of Campania “L. Vanvitelli” 7, Via L. De Crecchio 7, Naples, Italy;4. Sabinsa Corporation, East Windsor, NJ, United States |
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| Abstract: | The discovery of Vascular Endothelial Growth Factor (VEGF), the key modulator of angiogenesis, has triggered intensive research on anti-angiogenic therapeutic modalities. Although several clinical studies have validated anti-VEGF therapeutics, with few of them approved by the U.S. Food and Drug Administration (FDA), anti-angiogenic therapy is still in its infancy. Phytochemicals are compounds that have several metabolic and health benefits. Curcumin, the yellow pigment derived from turmeric (Curcuma longa L.) rhizomes, has a wide range of pharmaceutical properties. It has also been shown to inhibit VEGF by several studies. In this review, we elaborate the effect of curcumin on VEGF and angiogenesis and its therapeutic application. |
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| Keywords: | Curcumin vascular endothelial growth factor breast cancer age-related macular degeneration angiogenesis |
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