Management of hyperuricemia through dietary polyphenols as a natural medicament: A comprehensive review |
| |
| Authors: | Arshad Mehmood Muhammad Nadeem Ali Raza Nawazish Ali |
| |
| Affiliation: | 1. Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, China;2. Beijing Engineering and Technology Research Center of Food Additives, School of Food and Chemical Engineering, Beijing Technology and Business University, Beijing, China;3. Institute of Food Science and Nutrition, University of Sargodha, Sargodha, Pakistan;4. Institute of Food Science and Nutrition, University of Sargodha, Sargodha, Pakistan |
| |
| Abstract: | Hyperuricemia, a condition due to high serum uric acid level and is notorious to health. It is considered to be a potent risk factor for gout and dramatically associated in the development of many chronic diseases such as malignant tumor, cardiovascular disorders and renal failure. Modern innovative medicinal and therapeutic interventions are underlying these days to combat hyperuricemia. Previously reported studies revealed the significant impact of dietary polyphenols (e.g. anthocyanins, phenolic acids, flavonoids etc.) against hyperurecemia disorder. Dietary plant polyphenols, unlike anti- hyperuricemic agents, are not reported to have any side effects in curing hyperuricemia. The current comprehensive review figure outs the use of dietary polyphenols as a natural remedy for the management of hyperuricemia. The sources, affiliated pathways, mode of actions and factors affecting their efficiency to prevent hyperuricemia are deeply discussed in this article. Additionally, limitations and suggestions regarding previously reported studies are also highlighted. |
| |
| Keywords: | Hyperuricemia gout xanthine oxidase uric acid therapeutic interventions polyphenols mode of action |
|
|
