Postpartum depression and vitamin D: A systematic review |
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Authors: | Shirin Amini Reza Amani |
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Affiliation: | 1. Department of Nutrition, Nutrition and Metabolic Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;2. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran |
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Abstract: | Postpartum depression (PPD) is a prevalent mood disorder estimated to affect 20%–40% of women worldwide after childbirth. In recent studies, the effect of vitamin D on prevention of mood disorders and depression has been investigated, but it is still unclear how vitamin D may affect PPD. The evidence on the relevance between vitamin D deficiency and PPD is inconsistent, and assessment of the recent literature has not previously been carried out. Moreover, there are few clinical studies on PPD and vitamin D supplementation. Five studies have so far assessed the relationship between the levels of vitamin D and PPD. Findings from cohort studies suggest that vitamin-D deficiency is related to the incidence of PPD and vitamin D may play a significant role in the recovery of women with PPD, but it is uncertain whether these actions are the effect of vitamin D on the function of hypothalamic-pituitary-adrenal (HPA) axis, the levels of estradiol, serotonin, pro-inflammatory cytokines, and/or of other mechanisms involved in PPD. |
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Keywords: | Depression Pregnancy Postpartum Period Vitamin D Review |
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