Cerebral arterial inflow assessment with F-FDG PET: Methodology and feasibility

Positron emission tomography (PET) with ¹⁸fluorodeoxyglucose (¹⁸F-FDG) is increasingly used in neurology. The measurement of cerebral arterial inflow (QA) using ¹⁸F-FDG complements the information provided by standard brain PET imaging. Here, injections were performed after the beginning of dynamic acquisitions and the time to arrival (t0) of activity in the gantry's field of view was computed. We performed a phantom study using a branched tube (internal diameter: 4 mm) and a ¹⁸F-FDG solution injected at 240 mL/min. Data processing consisted of (i) reconstruction of the first 3 s after t0, (ii) vascular signal enhancement and (iii) clustering. This method was then applied in four subjects. We measured the volumes of the tubes or vascular trees and calculated the corresponding flows. In the phantom, the flow was calculated to be 244.2 mL/min. In each subject, our QA value was compared with that obtained by quantitative cine-phase contrast magnetic resonance imaging; the mean QA value of 581.4 ± 217.5 mL/min calculated with ¹⁸F-FDG PET was consistent with the mean value of 593.3 ± 205.8 mL/min calculated with quantitative cine-phase contrast magnetic resonance imaging. Our ¹⁸F-FDG PET method constitutes a novel, fully automatic means of measuring QA.