Prolonged release from PLGA/HAp scaffolds containing drug-loaded PLGA/gelatin composite microspheres |
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Authors: | Gongwen Tang Hong Zhang Yunhui Zhao Xiao Li Xiaoyan Yuan Min Wang |
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Affiliation: | (1) School of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300072, China;(2) Department of Mechanical Engineering, Faculty of Engineering, The University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong; |
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Abstract: | Porous scaffolds that can prolong the release of bioactive factors are urgently required in bone tissue engineering. In this
study, PLGA/gelatin composite microspheres (PGMs) were carefully designed and prepared by entrapping poly(l-lactide-co-glycolide) (PLGA) microspheres (PMs) in gelatin matrix. By mixing PGMs with PLGA solution directly, drug-loaded PLGA/carbonated
hydroxyapatite (HAp)/PGMs composite scaffolds were successfully fabricated. In vitro release of fluorescein isothiocyanate-dextran
(FD70S) as a model drug from the scaffolds as well as PMs and PGMs was studied by immersing samples in phosphate buffered
saline (pH = 7.4) at 37°C for 32 days. Compared with PMs, PGMs and PLGA/HAp/PGMs scaffolds exhibited slow and steady release
behavior with constant release rate and insignificantly original burst release. The swelling of PGMs, diffusion of drugs,
and degradation of polymer dominated the release behaviors synergistically. The PLGA/HAp/PGMs scaffold offers a novel option
for sequential or simultaneous release of several drugs in terms of bone regeneration. |
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