Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities |
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Authors: | Yin-Shiou Lin Sheng-Hsuan Chen Wei-Jan Huang Chao-Hsiang Chen Mei-Yin Chien Shyr-Yi Lin Wen-Chi Hou |
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Affiliation: | 1. School of Pharmacy, Taipei Medical University, Taipei, Taiwan;2. Department of Internal Medicine, Taipei Medical University, Taipei, Taiwan;3. Department of Internal Medicine, Mennonite Christian Hospital, Hualien, Taiwan;4. Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan;5. Ko Da Pharmaceutical Co., Ltd., and Néctar Valley Biopharma Inc., TaoYuan, Taiwan;6. Department of Primary Care Medicine, Taipei Medical University Hospital, Taipei, Taiwan;g Department of General Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;h Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei, Taiwan |
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Abstract: | The tyrosinase inhibitory and antioxidant activities of four nicotinic acid derivatives, namely, nicotinamide, methyl nicotinate, nicotinic acid hydroxamate (NAH), N-methyl nicotinic acid hydroxamate (NAH-M), and kojic acid, were studied. The tyrosinase inhibitory activity was found to follow the trend: NAH > kojic acid > NAH-M > methyl nicotinate > nicotinamide. The concentrations of half-inhibition (IC50) of NAH against monophenolase and diphenolase activity were 2 and 1 μM, respectively; the inhibition mode was a mixed-type in the former and an uncompetitive type in the latter. In the antioxidant activity assays, NAH and NAH-M, but not nicotinamide or methyl nicotinate, showed dose-dependent DPPH radical scavenging activity, and their corresponding IC50 values were 65.81 and 125 μM, respectively. NAH and NAH-M also showed hydroxyl radical scavenging activity and anti-low-density-lipoprotein peroxidation. These results indicate that NAH and NAH-M have the potential to be useful in cosmetics or food processing, and therefore, they should be investigated further. |
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Keywords: | Antioxidant activity Kojic acid Nicotinic acid hydroxamate (NAH) Tyrosinase |
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