Antibacterial activity of Thai edible plants against gastrointestinal pathogenic bacteria and isolation of a new broad spectrum antibacterial polyisoprenylated benzophenone,chamuangone |
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Authors: | A. Sakunpak P. Panichayupakaranant |
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Affiliation: | 1. Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand;2. Phytomedicine and Pharmaceutical Biotechnology Research Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand |
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Abstract: | Twenty-two edible plant extracts were subjected to evaluation of their antibacterial activity against some gastrointestinal pathogenic bacteria, including Escherichiacoli, Salmonella typhimurium, Salmonella typhi, Shigella sonnei and Helicobacter pylori using the disc diffusion and broth microdilution methods. Sixteen of the plant extracts exhibited antibacterial activity against one or more tested bacteria. Only Garcinia cowa leaf extracts exhibited antibacterial activity against all tested bacteria. Purification of the ethyl acetate extract of G. cowa leaves using an antimicrobial assay-guided isolation afforded a new polyprenylated benzophenone, chamuangone, that exhibited satisfactory antibacterial activity against Streptococcus pyogenes (minimum inhibitory concentration (MIC) 7.8 μg/ml), Streptococcus viridans and H. pylori (MICs 15.6 μg/ml), and Staphylococcus aureus, Bacillus subtilis and Enterococcus sp. (MICs 31.2 μg/ml). |
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Keywords: | Garcinia cowa Antibacterial Antimicrobial Chamuangone Benzophenone |
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